Work

Recent advances in distal tubular potassium handling

Year: 2011

Type: review

Abstract: It is well known that sodium reabsorption and aldosterone play important roles in potassium secretion by the aldosterone-sensitive distal nephron. Sodium- and aldosterone-independent mechanisms also exist. This review focuses on some recent studies that provide novel insights into the sodium- and aldosterone-independent potassium secretion by the aldosterone-sensitive distal nephron. In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. We also discuss outstanding questions and propose working models for future investigation.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00742.2010

Authors: Aylin R. Rodan, Chih-Jen Cheng, Chou-Long Huang

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Diabetes and Digestive and Kidney Diseases