Work

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Year: 2009

Type: article

Abstract: : A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies. Keywords: molecular imaging, liposome, angiogenesis, breast cancer, small animal imaging, micro-CT

Source: International Journal of Nanomedicine

DOI: 10.2147/ijn.s7881

Author: Samei

Institution: Duke University

Language: English

Topic: Medical Imaging Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836