Work

In vivo dual modality contemporaneous imaging of different tumor reactive T-cell subpopulations

Year: 2005

Type: article

Abstract: Background: Identification of the in vivo functions of T-cell subpopulations in vivo is critical for understanding their interactions in the course of adoptive immune cell therapy. The quantitation of T-cell subpopulations in tissues would also allow for the assessment of the proliferation potential of these cells. Previously, we have used various applications of HSV1-tk PET and firefly Luciferase reporter gene imaging for the generation of cell trafficking images. We have combined these two imaging options to assess CD4 and CD8 T-cell populations and to correlate cell numbers and image intensity using microPET and bioluminescent imaging (BLI).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2004.12.171

Authors: M.M. Doubrovin, E.S. Doubrovina, S. Cai, R.G. Blasberg, R.J. O’Reilly

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Medical Imaging Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650