Human Cardiovascular Disease IBC Chip-Wide Association with Weight Loss and Weight Regain in the Look AHEAD Trial
Year: 2013
Type: article
Abstract: BACKGROUND/AIMS: The present study identified genetic predictors of weight change during behavioral weight loss treatment. METHODS: Participants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Analyses focused on associations of single nucleotide polymorphisms (SNPs) on the Illumina CARe iSelect (IBC) chip (minor allele frequency >5%; n = 31,959) with weight change at year 1 and year 4, and weight regain at year 4, among individuals who lost ≥ 3% at year 1. RESULTS: Two novel regions of significant chip-wide association with year-1 weight loss in ILI were identified (p < 2.96E-06). ABCB11 rs484066 was associated with 1.16 kg higher weight per minor allele at year 1, whereas TNFRSF11A, or RANK, rs17069904 was associated with 1.70 kg lower weight per allele at year 1. CONCLUSIONS: This study, the largest to date on genetic predictors of weight loss and regain, indicates that SNPs within ABCB11, related to bile salt transfer, and TNFRSF11A, implicated in adipose tissue physiology, predict the magnitude of weight loss during behavioral intervention. These results provide new insights into potential biological mechanisms and may ultimately inform weight loss treatment.
Source: Human Heredity
DOI: 10.1159/000353181
Institutions: Brown University, Miriam Hospital, Tufts University, Tufts Medical Center, Icahn School of Medicine at Mount Sinai, Karger Publishers (Switzerland), University of Washington, VA Puget Sound Health Care System, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of Tennessee Health Science Center, Wake Forest University Health Sciences, Wake Forest University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: G1149464818, G1153163889, G1187123934, G1559150778, G1561916549, G1625418467, G1681235271, G1789861183, G1825392443, G1895210975, G1898137507, G1902398179, G2037811546, G2115812462, G220748524, G2247787434, G2279102038, G241913450, G2456504948, G2469879864, G2519210884, G2784927490, G2875079641, G3033840998, G3041424743, G3085877500, 05/16 Action for Health in Diabetes Extension Study - Research Project, G3237517486, General Clinical Research Center, G3422150604, General Clinical Research Center, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, G3728863030, University of Pittsburgh Clinical and Translational Science Institute, G386878553, G4140582021, G4342345827, G4451789618, G4623107666, G474757791, G5085995034, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, G5800301348, G677419319, G7244940528, G7376939847, Obesity/Nutrition Research Center, 12/16 Action for Health in Diabetes Extension Study Research Project, G881343144, Diabetes Research Center, G900410922, G955307958, G980169708
OpenAlex ID: W2095056223