Work

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Year: 1999

Type: review

Abstract: Perspective Figure 1 Schematic illustration of major signaling pathways of insulin action.The phosphorylated insulin receptor binds and phosphorylates IRS proteins and Shc, which bind differentially to various downstream signaling proteins.PI3-kinase is critical for metabolic actions of insulin, such as glucose transport, glycogen synthesis, and protein synthesis, whereas Grb-2/SOS complex, which activates the MAP kinase cascade, is critical in mitogenic response.PI3-kinase probably modulates the mitogenic response as well.This series continues from the March 1999, no.6, issue.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci6609

Authors: Antti Virkamäki, Kohjiro Ueki, C. Ronald Kahn

Institutions: Joslin Diabetes Center, Harvard University

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Foundation for the Study of Diabetes, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases