Work

The ovary as a source of alpha-ecdysone in an adult mosquito.

Year: 1975

Type: article

Abstract: The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct determination. Ovariectomy reduced the concentration of ecdysone in the adult after a blood meal. Qualitative analysis of whole-body extracts indicated beta-ecdysone to be the principal species present. Thus the ovaries appear to secrete a prohormone, alpha-ecdysone, which is converted to beta-ecdysone. Beta-ecdysone plays a significant role in stimulating egg development in the adult mosquito and may have reproductive roles in other insects.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.72.8.3255

Authors: H H Hagedorn, J D O'Connor, M S Fuchs, B Sage, D A Schlaeger, M K Bohm

Institutions: University of Notre Dame, University of Massachusetts Amherst, University of California, Los Angeles, University of Saint Francis

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2095357678

FWCI: 6.75

Cites: 27

Cited by: 408

Related to: 10