Year: 2011
Type: review
Abstract: Homeostasis of cardiac function requires significant adjustments in sarcomeric protein phosphorylation. The existence of unique peptides in cardiac sarcomeres, which are substrates for a multitude of kinases, strongly supports this concept (1). We focus here on the troponin complex of the thin filaments, which contain two major proteins that participate in these phosphoryl group transfer reactions: the inhibitory protein (cardiac troponin (cTn)2 I) and the tropomyosin (Tm)-binding protein (cTnT).
Source: Journal of Biological Chemistry
Authors: R. John Solaro, Tomoyoshi Kobayashi
Institution: University of Illinois Chicago
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
Awards: G1751552741, G1919541076, Molecular Mechanism of Troponin Function in Health and Disease, G3242908336, Modulation of Ca Control of Cardiac Myofibrils, Troponin Modulation in Heart Failure, G4206234062, MODULATION OF CALCIUM CONTROL OF CARDIAC MYOFIBRILS, Integrated Mechanisms of Cardiac Maladaptation, G9000173869
OpenAlex ID: W2095467143