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Inside Cover: North‐ and South‐Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti‐HIV Activity (ChemMedChem 8/2009)

Year: 2009

Type: article

Abstract: The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle (nmax=7 °) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening of the embedded cyclopentene ring provides active compounds against HOS cells infected with HIV. For more details, see the Full Paper by V. E. Marquez et al. on p. 1354 ff.

Source: ChemMedChem

DOI: 10.1002/cmdc.200990036

Authors: Pamela L. Russ, Maria J. Gonzalez‐Moa, B. Christie Vu, Dina M. Sigano, James A. Kelley, Christopher C. Lai, Jeffrey R. Deschamps, Stephen H. Hughes, Victor E. Marquez

Institutions: National Institutes of Health, National Cancer Institute, Arizona State University, United States Naval Research Laboratory

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2095566657

FWCI:

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