Work

SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster

Year: 2007

Type: preprint

Abstract: Post-translational modification of nucleosomal histones has been suggested to contribute to epigenetic transcriptional memory. We describe a case of transcriptional memory in yeast where the rate of transcriptional induction of GAL1 is regulated by the prior expression state. This epigenetic state is inherited by daughter cells, but does not require the histone acetyltransferase, Gcn5p, the histone ubiquitinylating enzyme, Rad6p, or the histone methylases, Dot1p, Set1p, or Set2p. In contrast, we show that the ATP-dependent chromatin remodeling enzyme, SWI/SNF, is essential for transcriptional memory at GAL1. Genetic studies indicate that SWI/SNF controls transcriptional memory by antagonizing ISWI-like chromatin remodeling enzymes.

Source: Genes & Development

DOI: 10.1101/gad.1506607

Authors: Sharmistha Kundu, Peter J. Horn, Craig L. Peterson

Institution: University of Massachusetts Chan Medical School

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G1480332753, Analysis of the yeast SWI1, SWI2, and SWI3 proteins, Analysis of the yeast SWI1, SWI2, and SWI3 proteins, G9000036088