Year: 2014
Type: review
Abstract: Inflammation contributes to many of the characteristics of plaques implicated in the pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only regulate the properties of plaques that precipitate acute coronary syndromes but also modulate the clinical consequences of the thrombotic complications of atherosclerosis. This synthesis will provide an update on the fundamental mechanisms of inflammatory responses that govern acute coronary syndromes and also highlight the ongoing balance between proinflammatory mechanisms and endogenous pathways that can promote the resolution of inflammation. An appreciation of the countervailing mechanisms that modulate inflammation in relation to acute coronary syndromes enriches our fundamental understanding of the pathophysiology of this important manifestation of atherosclerosis. In addition, these insights provide glimpses into potential novel therapeutic interventions to forestall this ultimate complication of the disease.
Source: Circulation Research
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: Molecular Regulation of Atherosclerosis Regression - Renewal, Translational Program of Excellence in Nanotechnology, New Genes and Pathways Involved in Atherosclerosis, Autophagy in Advanced Atherosclerosis, HDL Structure and its Function in Atherosclerosis, Molecular Determinants of Arterial Remodeling in Atherogenesis, Specialized pro-resolving mediators in atherosclerosis, Regulation of LXR alpha by glucose & cholesterol in diabetes & atherosclerosis, Mechanisms of Atherogenesis in Insulin Resistance, Mechanisms and Consequences of Stress-Induced Macrophage Death in Atherosclerosis, G796380040, Diabetes-mediated effects on myeloid precursors and vascular complications, Mechanisms of Defective Efferocytosis in Atherosclerosis
OpenAlex ID: W2095709591