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Pure red cell aplasia following peripheral stem cell transplantation: complete response to a short course of high-dose recombinant human erythropoietin.

Year: 1994

Type: article

Abstract: We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia. Corticosteroid treatment was ineffective. Four months after transplantation rHuEpo was administered subcutaneously at a dose of 150 U/Kg per day, five days a week for 8 weeks. Treatment induced an erythropoietic response and corrected anemia. Response was maintained following discontinuation of rHuEpo. This study and previous reports indicate that high doses of rHuEpo given over a short time can resolve PRCA following autologous or allogeneic stem cell transplantation.

Source: PubMed

Authors: M Martelli, L Ponchio, Y Beguin, G Meloni, F Mandelli, M Cazzola

Institutions: Sapienza University of Rome, Istituti Clinici Scientifici Maugeri, Centre Hospitalier Universitaire de Liège, Policlinico San Matteo Fondazione

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2095745433

FWCI: 0.954

Cites: 12

Cited by: 18

Related to: 10