Work

Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat

Year: 2013

Type: article

Abstract: Photoacoustic imaging employing molecular overtone vibration as a contrast mechanism opens a new avenue for bond-selective imaging of deep tissues. Broad use of this modality is, however, hampered by the extremely low conversion efficiency of optical parametric oscillators at the overtone transition wavelengths. To overcome such a barrier, we demonstrate the construction and use of a compact, barium nitrite crystal-based Raman laser for photoacoustic imaging of C-H overtone vibrations. Using a 5-ns Nd∶YAG laser as the pumping source, up to 21.4 mJ pulse energy at 1197 nm was generated, corresponding to a conversion efficiency of 34.8%. Using the 1197 nm pulses, three-dimensional photoacoustic imaging of intramuscular fat was demonstrated.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.18.4.040502

Authors: Rui Li, Mikhail N. Slipchenko, Pu Wang, Ji-Xin Cheng

Institution: Purdue University West Lafayette

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Award: Vibrational Photoacoustic Microscopy for Bond-selective Tissue Analysis