Work

Making the jump: new insights into the mechanism of trans-translation

Year: 2008

Type: article

Abstract: The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.

Source: Journal of Biology

DOI: 10.1186/jbiol78

Authors: Jacek Wower, Iwona K Wower, Christian Zwieb

Institutions: Auburn University, The University of Texas Health Science Center at Tyler

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,686

Funder: National Institute of General Medical Sciences