Metabolic Syndrome and Cognitive Decline Among the Oldest Old in Okinawa: In Search of a Mechanism. The KOCOA Project
Year: 2011
Type: article
Study design: Observational Study
Abstract: The study aim was to test whether the metabolic syndrome or its components predicted cognitive decline among persons aged 80 years and older (mean 85.0 years). Participants were members of the "Keys to Optimal Cognitive Aging Project," a prospective cohort study in Okinawa, Japan. Metabolic syndrome was assessed at baseline. Cognitive functions were assessed annually for up to 3 years. One hundred and forty-eight participants completed at least one follow-up with 101 participating in all three assessments and 47 participating in two of the three assessments. The mean and median duration of follow-up were 1.8 and 2 years, respectively. Metabolic syndrome and four components were not associated with decline in global and executive cognitive functions. However, high glycosylated hemoglobin was associated with decline in memory function at the second follow-up. Our study supports accumulating evidence that the positive association between metabolic syndrome and cognitive function might not hold for the oldest old.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Shor-term and long-term effects of dietary intervention with Okinawan vegetable-rich traditional foods on clinical prameters including bood pressure., G233529046, A prospective cohort study for the prevention of cognitive impairment among the Okinawan elderly, G4380180953, Oregon Alzheimer's Disease Center, G51028572, Dietary pattern of traditional Okinawa is a useful tool for management of high blood pressure, G5977822913, Patterns and Predictors of Normal Cognitive Aging, Intervention trial of the traditional vegetable-rich Okinawa diet: From the perspective of behavior modification of community residents
OpenAlex ID: W2095883869