Year: 1998
Type: article
Abstract: Morris JC, Cyrus PA, Orazem J , et al. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease. Neurology1998 May; 50 : 1222 –30 [OpenUrl][1][Abstract/FREE Full Text][2] Question In patients with mild to moderate Alzheimer's disease (AD), is metrifonate safe and effective? 26 week randomised, double blind, placebo controlled trial. 24 ambulatory clinics in the US. 408 patients (mean age 74 y, 61% women) who had probable AD according to the criteria of the National Institute of Neurological and Communicative Diseases and Stroke and the Alzheimer's Disease and Related Disorders Association, a Mini-Mental State Examination score of 10–26, a modified Ischemia Scale score <4, body weight of 45–94 kg (98–207 lbs), and contact with a caregiver ≥4 times/week. Exclusion criteria included dementia from a cause other than probable AD; cognitive impairment from toxic, alcoholic, or traumatic causes; clinically important medical problems; and previous treatment with metrifonate. After a loading dose of metrifonate, 100–180 mg (2.0 mg/kg of body weight), for 2 … [1]: {openurl}?query=rft.jtitle%253DNeurology%26rft.stitle%253DNeurology%26rft.aulast%253DMorris%26rft.auinit1%253DJ.%2BC.%26rft.volume%253D50%26rft.issue%253D5%26rft.spage%253D1222%26rft.epage%253D1230%26rft.atitle%253DMetrifonate%2Bbenefits%2Bcognitive%252C%2Bbehavioral%252C%2Band%2Bglobal%2Bfunction%2Bin%2Bpatients%2Bwith%2BAlzheimer%2527s%2Bdisease%26rft_id%253Dinfo%253Apmid%252F9595967%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=neurology&resid=50/5/1222&atom=%2Febmental%2F1%2F4%2F116.atom
Source: Evidence-Based Mental Health
DOI: 10.1136/ebmh.1.4.116
Author: Roger Luckmann
Institution: University of Massachusetts Chan Medical School
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2095894225