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Immunologic Basis of Cardiovascular Disease in HIV-Infected Adults

Year: 2012

Type: article

Abstract: Cardiovascular complications are more common in human immunodeficiency virus-infected individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the risk of cardiovascular complications, suggesting that viral replication directly or indirectly causes vascular disease. Long-term effective antiretroviral therapy does not fully restore vascular health, and treated adults continue to have higher-than-expected rates of disease progression. Although this excess risk during therapy is likely due to multiple factors, a growing body of evidence suggests that chronic inflammation, which persists during effective antiretroviral therapy, is directly and causally associated with vascular dysfunction and the accelerated development of atherosclerosis.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jis200

Authors: Priscilla Y. Hsue, Steven G. Deeks, Peter W. Hunt

Institutions: San Francisco General Hospital, University of California, San Francisco

Language: English