Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals
Year: 2010
Type: article
Study design: Observational Study
Abstract: Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
Funders: Howard Hughes Medical Institute, Emory University, National Institutes of Health, Center for AIDS Research, University of Washington, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Family Planning Promotion in HIV Infected Zambians, T cell regulation: CD4+CD25+ FOXP3+ T cells in acute and chronic HIV-1 infection, G2675028044, HETEROSEXUAL TRANSMISSION AND THE NATURAL HISTORY OF HIV, HETEROSEXUAL TRANSMISSION AND THE NATURAL HISTORY OF HIV, Emory AIDS International Training and Research Program, G6113675784, CTL and HIV Polymorphisms in Heterosexual Transmission, Couples HIV Counseling & Testing in two African capitals, Virologic Correlates of Heterosexual Transmission, G9000034708, Center for AIDS Research at Emory University
OpenAlex ID: W2096054724