Work

Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway

Year: 2004

Type: article

Abstract: TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the telomerase reverse transcriptase gene, indicating that embryonic lethality is not the result of telomerase-dependent changes in telomere length or function. Our findings suggest that TIN2 has a role independent of telomere length regulation that is essential for embryonic development and cell viability.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.24.15.6631-6634.2004

Authors: Y. Jeffrey Chiang, Sahn-Ho Kim, Lino Tessarollo, Judith Campisi, Richard J. Hodes

Institutions: National Cancer Institute, National Cancer Institute, National Cancer Institute, Lawrence Berkeley National Laboratory, Center for Cancer Research, National Institutes of Health, National Institute on Aging

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2096107753

FWCI: 2.861

Cites: 24

Cited by: 86

Related to: 10