Work

Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa

Year: 1997

Type: article

Abstract: MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including beta-lactams targeted to the periplasm.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.41.9.2009

Authors: K K Wong, K Poole, N Gotoh, R E Hancock

Institution: University of British Columbia

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2096162505

FWCI: 1.557

Cites: 33

Cited by: 21

Related to: 10