Inflammation marker and risk of pancreatic cancer: a nested case–control study within the EPIC cohort
Year: 2012
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. RESULTS: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. CONCLUSION: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer.
Source: British Journal of Cancer
DOI: 10.1038/bjc.2012.172
Authors: V A Grote, R Kaaks, A Nieters, A Tjønneland, J Halkjær, K Overvad, M R Skjelbo Nielsen, M C Boutron-Ruault, F Clavel-Chapelon, A Racine, B Teucher, S Becker, T Pischon, H Boeing, A Trichopoulou, C Cassapa, V Stratigakou, D Palli, V Krogh, R Tumino, P Vineis, S Panico, L Rodríguez, E J Duell, M-J Sánchez, M Dorronsoro, C Navarro, A B Gurrea, P D Siersema, P HM Peeters, W Ye, M Sund, B Lindkvist, D Johansen, K-T Khaw, N Wareham, N E Allen, R C Travis, V Fedirko, M Jenab, D S Michaud, S-C Chuang, D Romaguera, H B Bueno-de-Mesquita, S Rohrmann
Institutions: German Cancer Research Center, University Medical Center Freiburg, Danish Cancer Society, Aarhus University, Aarhus University Hospital, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, University Hospital Leipzig, Max Delbrück Center, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Hellenic Health Foundation, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Italian institute for Genomic Medicine, Imperial College London, Federico II University Hospital, University of Naples Federico II, Gobierno del Principado de Asturias, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Basque Government, Servicio Murciano de Salud, Instituto de Salud Pública de Navarra, University Medical Center Utrecht, University of Cambridge, Umeå University, University of Gothenburg, Lund University, Skåne University Hospital, MRC Epidemiology Unit, University of Oxford, Centre international de recherche sur le cancer, Brown University, National Institute for Public Health and the Environment, Institute of Social and Preventive Medicine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Wellcome Trust, World Cancer Research Fund International, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, European Commission, Deutsche Forschungsgemeinschaft, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Stavros Niarchos Foundation, NordForsk, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
OpenAlex ID: W2096319211