Work

Racial and ethnic differences in subclinical myocardial function: the Multi-Ethnic Study of Atherosclerosis

Year: 2011

Type: article

Abstract: BACKGROUND: Racial/ethnic differences in the incidence and severity of heart failure (HF) are not well understood, but may be related to pre-existing variations in myocardial function. OBJECTIVE: To examine racial/ethnic differences in regional myocardial function among asymptomatic individuals free of known cardiovascular disease. DESIGN, SETTING AND PATIENTS: The Multi-Ethnic Study of Atherosclerosis is a prospective, observational study of individuals without baseline cardiovascular disease, representing four major racial/ethnic groups. A total of 1099 study participants underwent cardiac MRI with tissue tagging; for each study, peak systolic strain (Ecc) and strain rate (SRs) were determined in four left ventricular (LV) regions. MAIN OUTCOME MEASURES: Multiple linear regression was used to analyse the relationship between race/ethnicity and regional strain (Ecc and SRs) while adjusting for cardiovascular risk factors. RESULTS: Compared with other racial/ethnic groups, Chinese-Americans had the greatest magnitude of Ecc in a majority of LV regions (-19.60±3.78, p<0.05); Chinese-Americans also had the greatest absolute values for SRs in all regions, reflecting higher rate of systolic contraction (-2.01±0.76, p<0.05). Conversely, African-Americans had the lowest Ecc values (-17.50±4.00, p<0.05) in the majority of wall regions while Hispanics demonstrated the lowest rate of contractility in all wall regions (-1.44±0.50, p≤0.001) in comparison with the other racial/ethnic groups. These race-based differences remained significant in the majority of LV wall regions after adjusting for multiple variables, including hypertension and LV mass. CONCLUSIONS: Important race-based differences in regional LV systolic function in a large cohort of asymptomatic individuals have been demonstrated. Further research is needed to investigate the possible mechanisms related to the race/ethnicity-based variations found in this study.

Source: Heart

DOI: 10.1136/hrt.2010.209452