A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor.
Year: 1988
Type: article
Abstract: This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function.
Authors: J T Sowder, C L Chen, L L Ager, M M Chan, M D Cooper
Institutions: University of Alabama, University of Alabama at Birmingham
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Awards: G3184592862, G718442997, G81528624
OpenAlex ID: W2096482972