Work

HLA‐Bw4Homozygosity Is Associated with an Impaired CD4 T Cell Recovery after Initiation of Antiretroviral Therapy

Year: 2008

Type: article

Study design: Observational Study

Abstract: We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P = .01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Source: Clinical Infectious Diseases

DOI: 10.1086/588479

Authors: Andri Rauch, David Nolan, Hansjakob Furrer, Elizabeth McKinnon, Mina John, Simon Mallal, Silvana Gaudieri, Huldrych F. Günthard, Patrick Schmid, Manuel Battegay, Bernard Hirschel, Amalio Telenti, Ian James, Swiss HIV Cohort Study

Institutions: University of Bern, Murdoch University, Royal Perth Hospital, University Hospital of Bern, The University of Western Australia, University Hospital Zurich, Kantonsspital St. Gallen, University Hospital of Basel, University Hospital of Geneva, University of Lausanne

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Award: G7507435735

OpenAlex ID: W2096715056

FWCI: 1.357

Cites: 16

Cited by: 29

Related to: 10