Work

Minding the Aging Brain: Are We Ready for Personalized Medicine?

Year: 2014

Type: editorial

Abstract: In this issue, Lineweaver and colleagues (1) report two remarkable findings: After cognitively normal older adults learn they have the ε4 allele of the APOE gene that increases the risk of developing Alzheimer's disease, they perform worse on measures of subjective and objective cognition compared with older adults who have this genotype but do not know their genotype.Conversely, those who learn that they do not carry an ε4 allele perform better on measures of subjective cognition compared with ε4-negative individuals who do not know they are ε4 negative.

Source: American Journal of Psychiatry

DOI: 10.1176/appi.ajp.2013.13111536

Authors: Jason Karlawish, Robert C. Green

Institutions: Brigham and Women's Hospital, Harvard University, University of Pennsylvania

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Johns Hopkins University, National Institutes of Health, National Institute on Aging, National Human Genome Research Institute