The thrombin receptor in human platelets is coupled to a GTP binding protein of the Gαq family
Year: 1995
Type: article
Abstract: The thrombin receptor is a G protein-coupled receptor, but the G proteins functionally coupled to this receptor in human platelets are not yet definitively identified. Thrombin stimulation of platelets leads to phospholipase C-mediated increases in intracellular calcium, and previous studies have suggested that the thrombin receptor is coupled to members of the Gq family. We now demonstrate direct GTPase activation by thrombin receptor activation peptide (TRAP) in human platelet membranes, and specific inhibition of TRAP-activated GTPase by antibodies to Gq. These data demonstrate functional coupling of the thrombin receptor to a member of the Gq family.
Source: FEBS Letters
Authors: Mary Lynn Benka, Matt Lee, Guang-Rong Wang, ShaAvhree Buckman, Anda Burlacu, Laura Cole, Ana DePina, Prabha Dias, Aaron Granger, Bob Grant, Amanda Hayward-Lester, Sher Karki, Suzanne Mann, Oana Marcu, Andre Nussenzweig, Peter Piepenhagen, Manisha Raje, Fabrice Roegiers, Sheree Rybak, Adrian Salic, Jennifer Smith-Hall, Jennifer Waters, Naoyuki Yamamoto, Judith Yanowitz, Karen Yeow, William B. Busa, Michael E. Mendelsohn
Institutions: Boston University, Marine Biological Laboratory
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2096805701