GC-MS and GC-IRD Studies on Dimethoxyphenethylamines (DMPEA): Regioisomers Related to 2,5-DMPEA
Year: 2011
Type: article
Abstract: A series of regioisomeric dimethoxyphenethylamines have a mass spectra essentially equivalent to the drug substance 2,5-dimethoxyphenethylamine (2,5-DMPEA). These substances have a molecular weight of 181, and major fragment ions in their electron ionization mass spectra at m/z 151/152. The trifluoroacetyl, pentafluoropropionyl, and heptafluorobutryl derivatives of these primary amines were prepared and evaluated by gas chromatography with mass spectrometry detection (GC-MS). The mass spectra for these derivatives do not show unique fragment ions to allow the specific identification of a particular isomer. Thus, GC-MS does not provide for the confirmation of identity of any one of the six isomers to the exclusion of the other five compounds. However, GC-MS does divide the compounds into two groups depending on the mass of the base peak. GC with infrared detection provides direct confirmatory data for the identification of 2,5-DMPEA from the other regioisomers involved in the study. Perfluoroacylated derivatives of the six regioisomeric dimethoxyphenethylamines were successfully resolved via capillary GC on a non-polar stationary phase consisting of 50% phenyl and 50% methyl polysiloxane (Rxi-50).
Authors: H. M. Maher, T. Awad, J. DeRuiter, C. R. Clark
Institutions: Alexandria University, Suez Canal University, Auburn University
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2096816614