Work

Spermatogonia: origin, physiology and prospects for conservation and manipulation of the male germ line

Year: 2005

Type: review

Abstract: In recent years, the scientific community has become increasingly interested in spermatogonia. Methodological breakthroughs, such as germ cell transplantation and spermatogonial culture combined with novel germ line transfection strategies, have provided interesting new opportunities for studying the physiology of spermatogonial stem cells and their interaction with the stem cell niche. Furthermore, intense research into pluripotent and adult stem cells has generated new insight into the differentiation pathway of germ line stem cells and has opened new perspectives for stem cell technologies. The present review briefly introduces the physiology of spermatogonial stem cells and discusses future directions of basic research and practical approaches applicable to livestock maintenance and animal reproduction.

Source: Reproduction Fertility and Development

DOI: 10.1071/rd05119

Authors: Jens Ehmcke, Karin Hübner, Hans R. Schöler, Stefan Schlatt

Institutions: University of Pittsburgh, Max Planck Institute for Molecular Biomedicine

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: University of Pittsburgh, Deutsche Forschungsgemeinschaft, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G3751629923, Novel Tools for Research on Primate Spermatogonia, G8188353290