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Malaria Enhances Expression of CC Chemokine Receptor 5 on Placental Macrophages

Year: 2001
Type: article
Study design: Observational Study
Abstract: Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5(+) maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells.
DOI: 10.1086/319248
Authors: Ariana N. Tkachuk, Ann M. Moormann, Judy A. Poore, Rosemary A. Rochford, Stephen W. Chensue, Victor Mwapasa, Steven R. Meshnick
Language: English
Field: Medicine
Open Access status: bronze
Funders: University of Michigan, Michigan State University, Wellcome Trust, National Institutes of Health, Centers for Disease Control and Prevention, College of Engineering, Michigan State University
OpenAlex ID: W2096862300
FWCI: 6.94
Cites: 30
Cited by: 77
Related to: 10