Assessment of the metabolic syndrome in predicting incident type 2 diabetes in a Chinese population
Year: 2005
Type: dissertation
Study design: Observational Study
Abstract: During the past decade Chinese people have gradually changed their lifestyles following the rapid development of the economy.Lifestyle changes in the population have increased the prevalence of type 2 diabetes and obesity, especially in urban areas.However, no study has been conducted on relationship between the metabolic syndrome and incident diabetes in China.This study was designed to evaluate the ability of the five definitions, major components and changes in features of the metabolic syndrome with respect to the prediction of type 2 diabetes in a Chinese population.The Beijing Project of National Diabetes Survey was carried out in 1994, and a follow-up study of 627 high-risk non-diabetic individuals at baseline was untaken in 1999.A total of 146 subjects developed diabetes during the 5-year follow-up.The definitions of the metabolic syndrome defined by the National Cholesterol Education Program (NCEP) Expert Panel and the European Group for the Study of Insulin Resistance (EGIR) were somewhat insensitive for predicting incident diabetes (especially in men), only detecting about 27% of Chinese men with incident diabetes.Both impaired fasting glucose and impaired glucose tolerance combined were associated with a 9-fold increased risk of incident diabetes in both men and women.Isolated impaired glucose tolerance was also associated with a 7.8-fold increased risk of future diabetes in Chinese men.Factor analysis revealed four factors, rather than only one factor, in non-diabetic and diabetic subjects.Blood pressure was not linked to insulin resistance.The urinary albumin excretion rate was associated with the glucose factor in diabetic subjects.The obesity and glucose factors strongly predicted the development of diabetes.An increase in the prevalence of obesity was associated with a 2.2-fold increased risk of the development of impaired glucose regulation or incident diabetes after adjustment for the confounding factors.The results suggest that further studies on the definition of the metabolic syndrome should focus on the potential ethnic differences in obesity and insulin resistance.In Chinese men, isolated impaired glucose tolerance is a better predictor of incident diabetes than impaired fasting glucose.Different physiological processes associated with various components of the metabolic syndrome contain unique information about diabetes risk.Microalbuminuria is more likely to be a complication of diabetes or hypertension than a marker of the metabolic syndrome.Obesity may be a more important risk factor for the development of impaired glucose regulation or diabetes than other features of the metabolic syndrome.
Source: Työväentutkimus Vuosikirja
Author: Jianjun Wang
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2097194840