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Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes

Year: 2013
Type: review
Abstract: Type 2 diabetes has rapidly emergedas a global health crisis. Becausepopulation-level genetic changes take many generations to occur, this epidemic is almost certainly primarily a consequence of recent environmental changes; nonetheless, diabetes does ap-pear to occur preferentially in genetically predisposed populations, which suggests that the effects of pre-existing suscepti-bility genes have been triggered by recent shifts in nongenetic factors. Predisposition is influenced by the level of certain environmental exposures, personal factors, access to good-quality primary care, and by genotype. Interac-tions between genetic and nongenetic risk
DOI: 10.2337/dc12-2211
Institutions: Harvard University, Lund University, Umeå University, University of Dundee, Broad Institute, Massachusetts General Hospital, Massachusetts Institute of Technology
Language: English
Subfield: Genetics
Open Access status: hybrid
Awards: G1290423768, A Human-Centered Pharmacogenomic Screen of Metformin Action, Study to Understand the Genetics of the Acute Response to Metformin & Glipizide, G6411832335, G8060355097, G970309226
OpenAlex ID: W2097474944
FWCI: 1.852
Cites: 75
Cited by: 154
Related to: 10