Work

Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

Year: 2010

Type: article

Abstract: Antimicrobial susceptibilities of 233 gram-positive and 180 gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 microg/ml. One bis-indole, MBX 1162, exhibited potent activity against all gram-negative strains, with MIC(90) values of 0.12 to 4 microg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00484-10

Authors: Michelle M. Butler, John D. Williams, Norton P. Peet, Donald T. Moir, Rekha G. Panchal, Sina Bavari, Dean L. Shinabarger, Terry L. Bowlin

Institutions: Microbiotix (United States), United States Army Medical Research Institute of Infectious Diseases

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2097500453

FWCI: 2.237

Cites: 8

Cited by: 40

Related to: 10