Year: 1947
Type: article
Abstract: In a previous communication from this clinic (1), three metabolic studies on the effect of estradiol benzoate on the calcium and phosphorus metabolisms of patients with post-menopausal osteoporosis were published in abstract form.The first objective of the present paper is to report these studies in detail, supplemented by 2 additional studies: one in which testosterone propionate by itself, and in combination with estradiol benzoate, was used; and another in which diethylstilbestrol by itself, and in combination with progesterone, was employed.The subject of the 1 The expense of these studies was defrayed by grants from the Josiah Macy, Jr. Foundation, from the Rocke- feller Foundation, and from the National Research Coun- cil (Committee for Researchin the Problems of Sex).A bed supported by the Mallinckrodt Chemical Company on the Metabolic Ward was used for part of these studies. 2 Presented in part at the twenty-sixth annual meeting of the Association for the Study of Internal Secretions, Atlantic City, New Jersey, June 8, 1942, in connection with a symposium on "Relation of Endocrines to Skeletal Development"; an outline of this presentation may be found in: Reifenstein, E. C., Jr.; Albright, F.; Parson, W.; and Bloomberg, E.: The effect of estradiol benzoate and of testosterone propionate and of combinations of both on post-menopausal osteoporosis and senile osteo- porosis, Endocrinology, 30: S1024 (1942).Also presented in part at the first annual meeting of the Amnerican Federation for Clinical Research, Minneapolis, Minn., April 20, 1942.Preliminary reports of part of these data may be found in: Albright, F.;
DOI: 10.1172/jci101787
Authors: Edward C. Reifenstein, Fuller Albright
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Massachusetts General Hospital
OpenAlex ID: W2097522558