Year: 1995
Type: dissertation
Study design: Observational Study
Abstract: Postprandial Triglyceride Response in Young Adult Men and Familial Risk for Coronary AtherosclerosisIn this cross-sectional study, the postprandial handling of a standardized oral lipid load (mean 397.6 grams), labelled with retinyl palmitate as a marker for chylomicrons and chylomicron remnants, was studied in 80 sons (mean age, 24.8 years) of patients with clinically manifest and angiographically proven severe coronary artery disease and in 55 sons (mean age 23.2 years) of angiographically negative controls.The objective was to determine whether an increased risk of coronary artery disease in young adults is related to changes in postprandial lipoprotein metabolism.Patients and controls were obtained from coronary angiography departments of four central general hospitals in the Netherlands.In both group of offspring postprandial levels of semm triglycerides, retinyl palmitate, and total cholesterol were measured during a 12 hour period.Both groups showed a marked rise in semm triglyceride and retinyl palmitate concentrations after the lipid load, reaching a maximum 4 to 6 hours postprandially.No changes in postprandial total cholesterol concentrations were observed in either group.In sons of patients with coronary artery disease postprandial hypertriglyceridemia was prolonged as compared to the sons of controls.Differences between groups mainly occurred between 6 and 12 hours after the lipid load.Similar results, although smaller and not statistically significant, were obtained with regard to postprandial retinyl palmitate, also showing differences mainly after 6 hours.It is concluded that healthy young sons of fathers with established coronary artery disease have a prolonged postprandial hypertriglyceridemia.These findings support the hypothesis that postprandial lipoprotein metabolism plays a role in atherogenesis.
Author: Cuno S.P.M. Uiterwaal
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2097760931