Work

Protein-passivated Fe3O4 nanoparticles: low toxicity and rapid heating for thermal therapy

Year: 2008

Type: article

Abstract: Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

Source: Journal of Materials Chemistry

DOI: 10.1039/b718745a

Authors: Bappaditya Samanta, Haoheng Yan, Nicholas O. Fischer, Jing Shi, D. Joseph Jerry, Vincent M. Rotello

Institution: University of Massachusetts System

Language: English

Topic: Characterization and Applications of Magnetic Nanoparticles

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Massachusetts, National Cancer Institute, National Institute of Environmental Health Sciences