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Association of the Kinesin Motor KIF1A with the Multimodular Protein Liprin-α

Year: 2003
Type: article
Abstract: Liprin-alpha/SYD-2 is a multimodular scaffolding protein important for presynaptic differentiation and postsynaptic targeting of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid glutamate receptors. However, the molecular mechanisms underlying these functions remain largely unknown. Here we report that liprin-alpha interacts with the neuron-specific kinesin motor KIF1A. KIF1A colocalizes with liprin-alpha in various subcellular regions of neurons. KIF1A coaccumulates with liprin-alpha in ligated sciatic nerves. KIF1A cofractionates and coimmunopreciptates with liprin-alpha and various liprin-alpha-associated membrane, signaling, and scaffolding proteins including alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors, GRIP/ABP, RIM, GIT1, and beta PIX. These results suggest that liprin-alpha functions as a KIF1A receptor, linking KIF1A to various liprin-alpha-associated proteins for their transport in neurons.
DOI: 10.1074/jbc.m211874200
Authors: Hyewon Shin, Michael Wyszynski, Kyung-Hye Huh, Juli G. Valtschanoff, Jae-Ran Lee, Jaewon Ko, Michel Streuli, Richard J. Weinberg, Morgan Sheng, Eunjoon Kim
Institutions: Korea Advanced Institute of Science and Technology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, University of North Carolina at Chapel Hill, Harvard University, Dana-Farber Cancer Institute
Language: English
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2097782660
FWCI: 3.853
Cites: 55
Cited by: 207
Related to: 10