Work

Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophilacase study

Year: 2007

Type: article

Abstract: A simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. This has been applied to eight Drosophila genomes. Existing techniques are either limited to a few hundred markers or a small number of taxa. This analysis uses over 14,000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. The results provide insight into evolutionary chromosomal dynamics and synteny analysis, and inform speciation studies.

Source: Genome biology

DOI: 10.1186/gb-2007-8-11-r236

Authors: Arjun Bhutkar, William M Gelbart, Temple F Smith

Institutions: Boston University, Harvard University

Language: English

Topic: Genome Rearrangement Algorithms

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,490

Funders: Harvard University, Broad Institute, National Institutes of Health, National Human Genome Research Institute