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Antibody-Dependent Cell-Mediated Virus Inhibition Antibody Activity Does Not Correlate With Risk of HIV-1 Superinfection

Year: 2013
Type: article
Study design: Observational Study
Abstract: Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.
DOI: 10.1097/qai.0b013e3182874d41
Authors: Donald N. Forthal, Gary Landucci, Bhavna Chohan, Barbra A. Richardson, R. Scott McClelland, Walter Jaoko, Catherine Blish, Julie Overbaugh
Institutions: University of California, Irvine, University of Nairobi, University of Washington, Fred Hutch Cancer Center, Stanford Medicine, Stanford University
Language: English
Subfield: Virology
Open Access status: green
OpenAlex ID: W2097832999
FWCI: 1.528
Cites: 22
Cited by: 22
Related to: 10