The Effects of 40 and 80 mg Hydro- alcoholic Extract of Crocus Sativus in the Treatment of Mild to Moderate Depression
Year: 2014
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background and purpose: Depressive disorder is a serious, potentially recurrent and very common in clinical practice with estimated lifetime prevalence of 21 % among the general population and approximately 11.3 of adults afflicted during a year. Saffron is a traditional spice which is used as a food additive. Recent studies indicate several therapeutic effects for saffron in psychiatric disorders, especially depression. Material and methods: We compared the efficacy of fluoxetine plus 40 mg hydro- alcoholic extract of crocus sativus and fluoxetine plus 80 mg hydro-alcoholic extract of crocus sativus, in a six-week double- blind, randomized clinical trial in the treatment of mild to moderate depressive disorders. Sixty adult patients were chosen who met the diagnostic and statistical criteria for mental disorders. Data was collected using Hamilton Depression Rating Scale, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), and structured clinical interviews. Patients were randomly assigned
Authors: Moosavi Seyed Mohammad, Mahshid Ahmadi, Amini Mojgan, Vazirzadeh Bita
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2097899146