The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: Evidence from a large collaborative study totaling 4,963 Subjects
Year: 2010
Type: article
Abstract: Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and candidate gene replication. We used the publicly available data of 947 families participating in the International Multi-Centre ADHD Genetics (IMAGE) study to conduct an in silico fine mapping study of previously associated genomic locations, and to attempt replication of previously reported candidate genes for intelligence. Although this sample was ascertained for attention deficit/hyperactivity disorder (ADHD), intelligence quotient (IQ) scores were distributed normally. We tested 667 single nucleotide polymorphisms (SNPs) within 15 previously reported candidate genes for intelligence and 29451 SNPs in five genomic loci previously identified through whole genome linkage and association analyses. Significant SNPs were tested in four independent samples (4,357 subjects), one ascertained for ADHD, and three population-based samples. Associations between intelligence and SNPs in the ATXN1 and TRIM31 genes and in three genomic locations showed replicated association, but only in the samples ascertained for ADHD, suggesting that these genetic variants become particularly relevant to IQ on the background of a psychiatric disorder.
DOI: 10.1002/ajmg.b.31149
Authors: Thais S. Rizzi, Alejandro Arias‐Vasquez, Nanda Rommelse, Jonna Kuntsi, Richard Anney, Philip Asherson, Jan Buitelaar, Tobias Banaschewski, Richard Ebstein, Dina Ruano, Sophie Van der Sluis, Christina A. Markunas, Melanie E. Garrett, Allison E. Ashley‐Koch, Scott H. Kollins, Arthur D. Anastopoulos, Narelle K. Hansell, Margaret J. Wright, Grant W. Montgomery, Nicholas G. Martin, Sarah E. Harris, Gail Davies, Albert Tenesa, David J. Porteous, John M. Starr, Ian J. Deary, Beate St. Pourcain, George Davey Smith, Nicholas J. Timpson, David M. Evans, Michael Gill, Ana Miranda, Fernando Mulas, Robert D. Oades, Herbert Roeyers, Aribert Rothenberger, Joseph Sergeant, Edmund Sonuga‐Barke, Hans Christoph Steinhausen, Eric Taylor, Stephen V. Faraone, Barbara Franke, Danielle Posthuma
Institutions: Amsterdam Neuroscience, Amsterdam UMC Location Vrije Universiteit Amsterdam, Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, King's College London, St. James's Hospital, Heidelberg University, Central Institute of Mental Health, National University of Singapore, Hebrew University of Jerusalem, Duke Medical Center, University of North Carolina at Greensboro, QIMR Berghofer Medical Research Institute, University of Edinburgh, Western General Hospital, Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Bristol, Medical Research Council, Universitat de València, Hospital Universitari i Politècnic La Fe, Ghent University, University of Göttingen, Vrije Universiteit Amsterdam, University of Southampton, University of Basel, University of Zurich, Aalborg University Hospital, North Denmark Region, SUNY Upstate Medical University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,920
Funders: Wellcome Trust, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke
OpenAlex ID: W2097904233