Work

A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

Year: 2011

Type: article

Abstract: A new enantioselective α-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.

Source: Chemical Science

DOI: 10.1039/c1sc00556a

Authors: Scott P. Simonovich, Jeffrey F. Van Humbeck, David W. C. MacMillan

Institution: Princeton University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Amgen, National Institute of General Medical Sciences

Award: New Strategies in Metallaphotoredox Catalysis