Year: 2014
Type: article
Abstract: Evolutionary elaboration of tissues starts with changes in the genome and location of the stem cells. For example, GABAergic interneurons of the mammalian neocortex are generated in the ventral telencephalon and migrate tangentially to the neocortex, in contrast to the projection neurons originating in the ventricular/subventricular zone (VZ/SVZ) of the dorsal telencephalon. In human and nonhuman primates, evidence suggests that an additional subset of neocortical GABAergic interneurons is generated in the cortical VZ and a proliferative niche, the outer SVZ. The origin, magnitude, and significance of this species-specific difference are not known. We use a battery of assays applicable to the human, monkey, and mouse organotypic cultures and supravital tissue to identify neuronal progenitors in the cortical VZ/SVZ niche that produce a subset of GABAergic interneurons. Our findings suggest that these progenitors constitute an evolutionary novelty contributing to the elaboration of higher cognitive functions in primates.
Source: Cell Reports
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
Awards: Development of the Cerebral Cortex in Mammals, SHH signaling and Interneuron progenitors in human subventricular zone, Generating and accelerating the maturation of Pvalb-fast spiking interneurons from human stem cells, G3324499255, G3441364023, G3970530310, Prenatal Development of the Visual System, Neurogenetic Processes in the Fetal Brain, Origin of Cortical Species-specific Distinctions., G8371568472
OpenAlex ID: W2098258328