Year: 2012
Type: article
Abstract: Further examination of BAFF SNPs in cGVHDA recent study of single nucleotide polymorphisms (SNPs) in the B-cell activating factor (BAFF) gene in patients revealed the potential relevance of genetic disparity in the BAFF gene to chronic graft-versus-host disease (cGVHD) development. 1Four recipient SNPs were reported to be predictors of cGVHD development after allogeneic hematopoietic stem cell transplantation.Two of these SNPs were in intron 2 (rs16972217; rs7993590), and 2 were in intron 3 (rs12428930; rs2893321).To better understand the nature of the association of these SNPs with cGVHD development, we conducted further analyses.While these 4 SNPs predicted cGVHD, they did not do so independently of each other.Even though they were deemed "tagSNPs" by Clark et al, TagSNPs are typically chosen to represent SNPs in regions of high linkage disequilibrium (LD) that allow coverage of a region (or haplotype) using a minimum number of polymorphisms. 1 Using the program Haploview 2 or the Genome Variation Server (http://gvs.gs.washington.edu/GVS/)used in the report, we found that all 4 SNPs were in very strong LD in whites of northern European descent (CEU; Figure 1).Thus, presuming the allele frequencies in this European-American patient population are similar to those in the reference CEU population, these SNPs cannot be independently prognostic of the cGVHD phenotype, because each SNP is highly predictive of the others (r 2 Ͼ 0.90).Therefore, rather than considering each SNP separately in a multivariate analysis, the haplotype(s) incorporating the
Source: Blood
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2098284519