Work

Neural tube malformations: complex segregation analysis and calculation of recurrence risks.

Year: 1979

Type: article

Abstract: Familial data on neural tube malformations in Great Britain were submitted to segregation analysis under the mixed model. Maternal and fetal factors cannot be discriminated in the absence of substantial bodies of data on spina bifida survivors who reproduce or on half-sibs. Early abortion studies would allow differential mortality in utero to be taken into account. After fitting the mixed and generalised single locus models, it is concluded that the multifactorial model can provisionally be used for calculation of recurrence risks. Pathogenic hypotheses implicating twinning seem to rest on little evidence.

Source: Journal of Medical Genetics

DOI: 10.1136/jmg.16.1.8

Authors: J M Lalouel, N E Morton, J Jackson

Institutions: University of Hawaiʻi at Mānoa, University of Hawaii System, University of Mississippi Medical Center

Language: English

Topic: Spinal Dysraphism and Malformations

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health