A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults
Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTα) may be important for the development of cerebral malaria (CM) and other SM syndromes. METHODS: An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the TNF, LTA and LTB genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic region. Generated P-values for SNPs spanning the LTA/TNF/LTB locus were corrected for multiple testing of all the SNPs and haplotype blocks within the region tested through 10,000 permutations. A global P-value of < 0.05 was considered statistically significant. RESULTS: No associations between SNPs in the TNF/LTA/LTB locus and susceptibility to SM in highland Papuan children and adults were found. CONCLUSIONS: These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.
Source: Malaria Journal
Authors: Louise M Randall, Enny Kenangalem, Daniel A Lampah, Emiliana Tjitra, Esther D Mwaikambo, Tjandra Handojo, Kim A Piera, Zhen Z Zhao, Fabian de Labastida Rivera, Yonghong Zhou, Karli M McSweeney, Lien Le, Fiona H Amante, Ashraful Haque, Amanda C Stanley, Tonia Woodberry, Ervi Salwati, Donald L Granger, Maurine R Hobbs, Ric N Price, J Brice Weinberg, Grant W Montgomery, Nicholas M Anstey, Christian R Engwerda
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W2098560404