Work

Generating Encoded Compound Libraries for Fabricating Microarrays as a High-Throughput Protein Ligand Discovery Platform

Year: 2013

Type: article

Abstract: We demonstrate an effective method for generating libraries of encoded compounds for fabricating large compound microarrays on solid supports. This method is based on one-bead, one-compound synthesis and employs a novel trilayer bead-partition scheme that ensures sufficient quantity of synthesized compounds releasable from each bead for compound microarray fabrication in high-throughput protein–ligand discovery assays. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]

Source: Synthetic Communications

DOI: 10.1080/00397911.2013.840728

Authors: Yung-Shin Sun, Yiyan Fei, Juntao Luo, Seth Dixon, James P. Landry, Kit S. Lam, Xiangdong Zhu

Institutions: Fu Jen Catholic University, Fudan University, SUNY Upstate Medical University, University of California Davis Medical Center, University of California, Davis

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2098633801

FWCI: 0.298

Cites: 49

Cited by: 3

Related to: 10