Work

Novel locus including FGF21 is associated with dietary macronutrient intake

Year: 2013

Type: review

Study design: Observational Study

Abstract: Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10(-5)) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (Pjoint = 7.9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.

Source: Human Molecular Genetics

DOI: 10.1093/hmg/ddt032

Authors: Audrey Y. Chu, Tsegaselassie Workalemahu, Nina P. Paynter, Lynda M. Rose, Franco Giulianini, Toshiko Tanaka, Julius S. Ngwa, Qibin Qi, Gary C. Curhan, Eric B. Rimm, David J. Hunter, Louis R. Pasquale, Paul M. Ridker, Frank B. Hu, Daniel I. Chasman, Lu Qi

Institutions: Brigham and Women's Hospital, Harvard University, National Institute on Aging, Boston University, Massachusetts Eye and Ear Infirmary

Language: English

Topic: Nutrition, Genetics, and Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: green

Funders: American Heart Association, Amgen, National Institutes of Health, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Women's Health Study: Continued Follow-Up, Obesity Genes, Energy Regulation in Response to Weight-Loss Diets, G151562090, G1528515809, G1861573265, G1861783600, Genetic Markers of CHD in Type 2 Diabetes, G229684361, Biochemical Markers in the nurses' Health Study Cohort, G2750880407, Genes and Environment Initiatives in Type 2 Diabetes, Biochemical and Genetic Markers of Type 2 Diabetes Risk, Boston Nutrition Obesity Research Center, Dietary and Hormonal Determinants of Cancer in Women, Genetics of Coronary Artery Disease in Type 2 Diabetes, G459566519, Epidemiology of Precursors to Type 2 Diabetes, G5869775930, CHARGE consortium: omics discovery for CVD and aging phenotypes, G6008908520, G6668842614, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, Training Program in the Epidemiology of CVD, Biochemical Markers in the Nurses? Health Study Cohort, G772621625, Women's Health Study: Continued Follow-up, DETERMINANTS OF MITOMYCIN C SENSITIVITY IN HUMAN TUMORS, RISK FACTORS FOR CVD IN WOMEN, Risk Factors for Ischemic Stroke in Women, G985071772

OpenAlex ID: W2098667700

FWCI: 1.496

Cites: 38

Cited by: 191

Related to: 10