Work

2-ethyl-5-(3-indolyl)oxazole from Streptomyces cinnamomeus discovered by chemical screening. Characterization and structure elucidation by X-ray analysis.

Year: 1982

Type: article

Abstract: In the lipophilic extracts from Streptomyces cinnamomeus 2-ethyl-5-(3-indolyl)oxazole (1a) was detected by chemical screening methods. The structure of the crystalline 1a was determined by spectroscopic and X-ray analysis. The new mono- and dibromo derivatives 1b and 1c are described. 1a is identical with pimprinethine and belongs to a group of microbial indole alkaloids, which can be regarded as masked tryptamine derivatives.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.35.549

Authors: MATHIAS NOLTEMEYER, GEORGE M. SHELDRICK, HANS-ULLRICH HOPPE, AXEL ZEECK

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Verband der Chemischen Industrie, Deutsche Forschungsgemeinschaft

OpenAlex ID: W2098944166

FWCI: 1.099

Cites: 18

Cited by: 39

Related to: 10