Work

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade

Year: 2013

Type: article

Abstract: We have created a non-human primate (NHP) model of GvHD. Here we determined whether mTOR inhibition with sirolimus and CD28:CD80/86 costimulation blockade with belatacept could combine synergistically to prevent this disease.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.079

Authors: Natalia Kozyr, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Divya Tiwari, Benjamin Watkins, Taylor Deane, Linda Stempora, Eric Elder, Natia Esiashvili, Joe Jenkins, Elizabeth Strobert, Anapatricia Garcia, Prachi Sharma, Cynthia Courtney, Cynthia Giver, Edmund K. Waller, Angela Mortari, Bruce R. Blazar, Leslie S. Kean

Institutions: Emory University, Emory University Hospital, University of Minnesota

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650

OpenAlex ID: W2099004385

FWCI:

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Related to: 10