Work

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus

Year: 1999

Type: preprint

Abstract: NeuroD, a bHLH transcription factor, is implicated in differentiation of neurons and pancreatic beta cells. NeuroD-null mice die shortly after birth due to severe neonatal diabetes. To examine if there is postnatal neuronal phenotype in these mice, we rescued them from neonatal lethality by introducing a transgene encoding the mouse neuroD gene under the insulin promoter. These mice survive to adulthood but display severe neurological phenotype due to neuronal deficit in the granule layers of the cerebellum and hippocampus. We show here that NeuroD is required for these postnatally generated microneurons to undergo proper differentiation, the absence of which results in cell death.

Source: Genes & Development

DOI: 10.1101/gad.13.13.1647

Authors: T. Miyata, T. Maeda, J. E. Lee

Institution: University of Colorado Boulder

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, Japan Society for the Promotion of Science, National Institute of Neurological Disorders and Stroke