Work

Human Immunodeficiency Virus Type 1 Coreceptor Preferences Determine Target T-Cell Depletion and Cellular Tropism in Human Lymphoid Tissue

Year: 2000

Type: article

Abstract: The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4(+) T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4(+) lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.

Source: Journal of Virology

DOI: 10.1128/.74.11.5347-5351.2000

Authors: Jean-Charles Grivel, Michael L. Penn, Daniel A. Eckstein, Birgit Schramm, Roberto F. Speck, Nancy W. Abbey, Brian Herndier, Leonid Margolis, Mark A. Goldsmith

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Gladstone Institutes, University of California, San Francisco

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Aeronautics and Space Administration, Gladstone Institutes, National Institutes of Health, University of California, San Francisco, National Institute of Allergy and Infectious Diseases

Awards: HIV CORECEPTORS--FUNCTION, SPECIFICITY AND PATHOGENESIS, G7374733369

OpenAlex ID: W2099122103

FWCI: 2.018

Cites: 14

Cited by: 71

Related to: 10